Faculty Profile  Faculty ProfileLast Modified Time: 11:40:23 AM Fri, 13 Feb 2015 
Dr. Pamela Anne Padilla
 Contact Information
Dr. Pamela Anne Padilla
Associate Professor-Biological Sciences
Contact address   Chestnut and Avenue C, 1155 Union Circle Box 305220, Denton, TX 76203     Office LocationLife Science Building B, Room No.: B220 
Email  ppadilla@unt.edu    Contact Number (940) 565-3614    Contact Number: (940) 891-6744    Padilla Lab Padilla Lab   
Graduate Faculty Membership Status: Full Membership -Permanent   
toggle toggle  Professional Preparation
 Degree Major/Thesis/Dissertation Institution Year
Doctor of Philosophy Biology/Molecular Genetics University of New Mexico 1998
Bachelor of Science Biology University of New Mexico 1993
toggle toggle Courses Taught By Semester --- Organized Classes will be uploaded from THECB Data file
SemesterSubjectCourse NumberSectionCourse NameCalculated Semester Credit HoursSyllabus 
Fall 2015BIOL4460001Eukaryotic Genetics  
Spring 2015BIOL3451001Genetics Download Syllabus
Fall 2014BIOL4460001Eukaryotic Genetics Download Syllabus
Spring 2014BIOL3451001Genetics  
Fall 2013BIOL4460001Eukaryotic Genetics  
Spring 2013BIOL3451001Genetics  
Fall 2012BIOL4460001Eukaryotic Genetics  
Spring 2012BIOL3451001Genetics Download Syllabus
Spring 2011BIOL3451001Genetics Download Syllabus
Spring 2010BIOL3451001Genetics468 
Fall 2009BIOL5460001Eukaryotic Genetics36 
Fall 2009BIOL4460001Eukaryotic Genetics21 
toggle toggle  Research and Expertise
Molecular Genetics
Padilla Lab Research
R esearch in the Padilla lab is funded by both National Institutes of Health and National Science Foundation. Her research program focuses on how organisms respond to and survive environmental stress. She is particularly interested in how organisms reversibly arrest developmental processes in response to environmental changes.
As a PhD student, Dr. Padilla studied starvation induced quiescence, using the genetic model system yeast. Her interest in stress response and arrest of biological processes has continued, yet the organisms she studies has expanded. As a post-doctoral fellow she described a state of suspended animation in both zebrafish embryos and C. elegans. Suspended animation is an arrest of observable biological processes such as development, cell division and behaviours such as motility.
Currently the focus of the Padilla lab is to use the genetic model system C. elegans to identify the molecular mechanisms regulating oxygen deprivation-induced suspended animation. Other projects of interest include how stress and the aging process are related at the genetic and cellular mechanistic level. Another research project involves the cellular changes that occur in killifish embryos in a state of diapause.
toggle toggle Appointments
Duration (YYYY - YYYY or Present)RankDepartment / SchoolCollege / OfficeUniversity / Company
2008-PresentAssociate ProfessorBiological SciencesCollege of Arts and ScienceUNT
2008Kavli Fellow  Kavli Frontiers and National Academy of Sciences
2002-2008Assistant ProfessorBiological SciencesCollege of Arts and ScienceUNT
1999-2002NSF Post-doctoral FellowBasic Sciences Fred Hutchinson Cancer Research Center
1998Research Assistant  University of New Mexico
1997Teaching Assistant, Cell Biology  University of New Mexico
1996MBRS Research Fellow  University of New Mexico
1994-1996Patricia Harris Research Fellow  University of New Mexico
1993Howard Hughes Research Scholarship  University of New Mexico
toggle toggle Faculty Workload
Duration (YYYY - YYYY)Percentage TeachingPercentage ResearchPercentage Service
toggle toggle Publications
  Type  Publications per page   
1  2 3 
  YearPublication  Type
Environmental and Genetic Preconditioning for Long-Term Anoxia Responses Requires AMPK in Caenorhabditis elegans
Bobby L. LaRue and Pamela A. Padilla
Refereed(Peer reviewed) Journals
NPP-16/Nup50 Function and CDK-1 Inactivation Are Associated with Anoxia-induced Prophase Arrest in Caenorhabditis elegans
Vinita A. Hajeri, Brent A. Little, Mary L. Ladage, Pamela A. Padilla
Molecular Biology of the Cell
Refereed(Peer reviewed) Journals
A reduction in ovulation or the male sex phenotype increases long-term anoxia survival in a daf-16 independent manner in Caenorhabditis elegans
Alex Mendenhall, Michelle LaBlanc, Desh Mohan, Pamela Padilla
Physiological Genomics, 36:267-278, 2009, first published Dec. 2, 2008 (Epub ahead of print)
Refereed(Peer reviewed) Journals
Genetic Interactions between the Spindle Checkpoint Genes and hcp-1 in C. elegans
Vinita Hajeri, Neil Stewart, Landon Moore, Pamela A. Padilla
Cell Division, February 2008
Refereed(Peer reviewed) Journals
Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the Major Sperm Protein Pathway
Molly Jud, Michael J Czerwinski, Megan Wood, Rachel A Young, Jeremy Bickel, Christopher Gallo, Emily Petty, Jennifer Mason, Brent A. Little, Pamela Padilla, and Jennifer A. Schisa
Developmental Biology, 2008
Refereed(Peer reviewed) Journals
toggle toggle Editorships
Duration (YYYY - YYYY or Present)OrganizationPositionClassification
2009GerontologyJournal Reviewer 
2008Cell ScienceJournal Reviewer 
2006GeneticsJournal Reviewer 
-2003, 2005Comparative Biochemistry and PhysiologyJournal Reviewer 
toggle toggle Lectures/Symposia
2009Mechanisms regulating anoxia-induced suspended animation in Caenorhabditis elegans Baylor University
2009Mechanisms regulating anoxia-induced suspended animation in Caenorhabditis elegans UNT Health Science Center
2009Ralf Baumeister (Freiburg, Germany)Host for Seminar Speaker 
2008Mechanisms Regulating Suspended Animation in Caenorhabditis elegans Texas Woman’s University
2008Mechanisms Regulating Suspended Animation in Caenorhabditis elegansInvited SpeakerBeckman Center, National Academy of Sciences, Annual Kavli Frontiers of Science Symposium
2008Child DevelopmentGuest LecturerCollege of Education
2008Jennifer Schisa (Central Michigan)Host for Seminar Speaker 
2008Jason Podrabsky (University of Oregon, Portland)Host for Seminar Speaker 
2008Andrew Dillin (Salk Institute)Host for Seminar Speaker 
2007Analysis of Oxygen Deprivation in C. elegans Texas Genetics Society Annual Conference, San Antonio Texas
2007Analysis of Oxygen Deprivation in C. elegans Harding University, Arkansas
2006-2007Human Disease and Model SystemsGuest Lecturer 
2006Ed Braun (U of Florida)Host for Seminar Speaker 
2005Oxygen deprivation in C. elegans UNTHSC, Seminar Cell Biology and Genetics Department
2005Genetic and Cellular Approaches for Studying Oxygen Deprivation in C. elegans University of New Mexico, Department of Biology
2005Pamela Larson (UT San Antonio)Host for Seminar Speaker 
2005Mike Herman (Kansas State)Host for Seminar Speaker 
2004Developmental BiologyGuest Lecturer 
2004Doug Chalker (Washington University)Host for Seminar Speaker 
2004Leon Avery (UT Southwestern Medical School)Host for Seminar Speaker 
2003Suspended Animation: Anoxia Induced Cell Cycle and Developmental Arrest in C. elegansSeminar Speaker (invited)University of Texas at San Antonio, Department of Biological Sciences MBRS
2003Anoxia Induced Cell Cycle and Developmental Arrest in C. elegansSeminar Speaker10. Texas Women’s University, Biology Department
2003Anoxia-Induced Suspended Animation in C. elegans 11. C. elegans International Meeting, UCLA
2003Oxygen Deprivation in C. elegans and ZebrafishInvited Seminar by UNTHSC Graduate Students12. UNT Health Science Center, Ft. Worth
2003Shane Kanatous (UT Southwestern Medical School)Host for Seminar Speaker 
2002Oxygen Deprivation in C. elegans and ZebrafishInvited talk by MBRS/MARC StudentsUniversity of California Los Angeles
2001Journalism and Science EducationGuest LecturerUniversity of Washington
1997Cell BiologyGuest LecturerUniversity of New Mexico
toggle toggle Patents
Year of AwardTitle of PatentDescription
2001Methods for inducing reversible stasis/Tissue and Cellular PreservationP. Padilla, M. Roth. Private company (Ikaria) has licensed this patent, royalties obtained.
toggle toggle Presentations and Projects
  Presentations/Projects per page   
1  2 3 4 5 6 7 8 9 10 11 12 13 
Start DateEnd DatePresentation/Project
2010 2010 UNTHSC, “Mechanisms regulating anoxia-induced suspended animation in Caenorhabditis elegans:, 2010. Invited Seminar
2010 2010 Larval Fish Conference, “Cell biological analysis of neuroglobin in Fundulus heteroclitus”, May 2010.
2010 2010 MIT, “Oxygen Deprivation: A regulator of a prophase checkpoint and suspended animation in C. elegans”, April 2010, Invited Seminar (Host: Bob Horvitz, Nobel Lauriat).
toggle toggle External Funding
 Performance PeriodTitleSponsorFundingRoleStatus
2004-2009Genetic and Cellular Analysis of C. elegans Exposed to AnoxiaNational Institutes of Health (RO1 GM069419-01A1), NIGMS$894,409OtherCompleted
2005Acquisition of a Spinning Disc Confocal Microsope PI: Dr. Dickstein, CoPI with Dr’s Root, Ayre and SchwarkUNT Internal Application$438,382Co-PICompleted
2005NIH- Supplement Grant to Promote Diversity in the Biomedical FieldNational Institutes of Health-NIGMS$14,000OtherCompleted
2003-2004Analysis of ODS-1 in C. elegans Exposed to AnoxiaNational Science Foundation Research Starter Grant$50,000OtherCompleted
2003Investigate the role the spindle checkpoint has in arresting C. elegans embryos exposed to anoxiaUNT Health Science Center, American Cancer Society Institutional Research Grant$10,000OtherCompleted
1999-2002Metazoan Response to Oxygen DeprivationNational Science Foundation Post-Doctoral$150,000OtherCompleted
2008-PresentCAREER: Use of C. elegans to Identify Alleles and Genotypes that Modulate Severe Anoxia SurvivalNational Sciences Foundation$639,556Principal InvestigatorActive
2004-PresentGenetic/Cellular Response to AnoxiaNational Institutes of Health Principal InvestigatorActive
toggle toggle Teaching
Eukaryotic Genetics


Physiological and Molecular Responses to Stress

toggle toggle Mentoring/Advising
Duration (YYYY - YYYY or Present)Student NameClassificationTypeProject/Thesis/Dissertation
2009-PresentTasha GarciaDoctor of PhilosophyGraduate Mentoring/Advising 
2008-PresentLee TonyDoctor of Philosophy StudentGraduate Mentoring/Advising 
2006-PresentBrent LittleDoctor of Philosophy StudentGraduate Mentoring/Advising 
-PresentSophia PetrichenkoTexas Academy of Math and Science Student 
-PresentHenry GrienerTexas Academy of Math and Science Student 
-PresentSahil KhetptelTexas Academy of Math and Science Student 
-PresentVibhu Bakshi Graduate Mentoring/Advising 
-PresentJennifer Copeland Graduate Mentoring/Advising 
-PresentAngela Wilson Graduate Mentoring/Advising 
-PresentAaron Binder Graduate Mentoring/Advising 
-PresentMark PavlyukovskyyTexas Academy of Math and Science Student 
-PresentVinita HajariPost Doctoral FellowGraduate Mentoring/Advising 
-PresentMary LadageDoctor of Philosophy StudentGraduate Mentoring/Advising 
-PresentMarcus Ventura Undergraduate Research 
2004-2010Bobby LaRueDoctor of Philosophy StudentGraduate Mentoring/Advising 
2009Jo GoyDoctor of Philosophy StudentGraduate Mentoring/Advising 
2007-2009Neil StewartMaster of Science, NIH Supplementary Research RecipientGraduate Mentoring/Advising 
2003-2008Vinita HajeriDoctor of Philosophy, Beth Baird Scholar, Texas Education Scholar, Outstanding International Student AwardGraduate Research 
2003-2008Alex MendenhallDoctor of Philosophy, Beth Baird ScholarGraduate Research 
 Ravi G. Graduate Mentoring/Advising 
 Sara Anvari Graduate Mentoring/Advising 
 Harita Veereshlingam Graduate Mentoring/Advising 
 Savita Ganesan Industry Mentoring/Advising 
 Dipesh Patel Graduate Mentoring/Advising 
 Gunisha Sagar Graduate Mentoring/Advising 
 Laurent Coque Graduate Mentoring/Advising 
 Brandon RobertsFormer Student, Texas Academy of Math and Science, Undergraduate at Air Force Academy 
 Uneeb RahmanFormer Student, Texas Academy of Math and Science, Undergraduate at Emory 
 Nicole ParkerFormer Student, Ph.D. program Mt. SinaiGraduate Mentoring/Advising 
 Jesus TrejoFormer Student, 1 publication, Medical School, Texas TechGraduate Mentoring/Advising 
 Tammy ChanFormer Student, Ph.D. program BaylorGraduate Mentoring/Advising 
 Michael VillarealFormer Student, High School TeacherGraduate Mentoring/Advising 
 Jeremy HolmanFormer Student, High School TeacherGraduate Mentoring/Advising 
 Randala HamdanFormer Student, Ph.D. Program M.D. AndersonGraduate Mentoring/Advising 
 Michelle LeBlancFormer Student, McNair Scholar, Honors Thesis, Ph.D. program NYUGraduate Mentoring/Advising 
 Jemma AlaracornFormer Student, Texas Academy of Math and Science, Regional Siemens Scholar, Undergraduate Student at Johns Hopkins, G. Seydoux Lab 
 Desh MohanFormer Student, Texas Academy of Math and Science, National Siemens Scholar, 1 publication, Undergraduate Student at MIT, R. Horvitz Lab (Nobel Laureate) 
 Jack WangFormer Student, Texas Academy of Math and Science, Goldwater Scholar, Undergraduate, Dartmouth; NIH Summer Research Scholarship 
 Sabrina PojarFormer Student, Accepted into MD program in ArizonaGraduate Mentoring/Advising 
toggle toggle Committees
Duration (YYYY - YYYY or Present)CommitteePositionClassification
2008-PresentPersonnel Affairs Committee Department/Division Committees & Councils
2008-PresentPromotion and Tenure Committee Department/Division Committees & Councils
2006-PresentNorth Texas Molecular Biology Federation Department/Division Committees & Councils
2009adhoc Committee for SACNAS conference CAS
2008Aging, Stress and Pathogenesis C. elegans Topic ConferenceCo-OrganizerUW-Madison
2007-2008Grant Review PanelPanelistNational Science Foundation
2007-2008Evolutionary Biologist Faculty Search Committee Department/Division Committees & Councils
2005-2007Biology Building Committee Department/Division Committees & Councils
2005-2006Developmental Biologist Faculty Search Committee (hired 2 faculty) Department/Division Committees & Councils
2005Organic Chemistry Search CommitteeExternal Faculty MemberCAS
2005Faculty Senate Committee on the Status of Women UNT
2004Ad Hoc Graduate Affairs Committee Department/Division Committees & Councils
2004Ad Hoc Beth Baird Gift Committee Department/Division Committees & Councils
toggle toggle Memberships
Duration (YYYY - YYYY or Present)OrganizationPositionClassification
 Genetics Society of America (GSA)MemberProfessional Organization
 American Society of Cell Biology (ASCB)MemberProfessional Organization
 American Neurological SocietyMemberProfessional Organization
 Society for Advancement of Chicano and Native Americans in Science (SACNAS)- Life Time MemberMemberProfessional Organization
toggle toggle Honors and Recognitions
YearTitleHonoring Organization
2010Glenn Scholars Visiting Scientist ProgramSalk Institute
2008Kavli FellowKavli Foundation, National Academy of Sciences
2005, 2007MentorMcNair Scholars
2004Outstanding MentorSiemens Westinghouse Scholarship Competitors (Jemma Alarcon, 2004 Semi-Finalist; Desh Mohan , 2005 National Finalist-ranked 4th in nation)
2004Invited ParticipantNational Academy of Sciences, Seventh Annual Japanese-American Beckman Frontiers of Science Symposium, Irvine CA
2002Travel AwardFASEB/NIH MARC Grant Writing Seminar
1999Phi Kappa Phi Honors AwardOutstanding Graduate Students
1999NSF Post-doctoral FellowNational Science Foundation
1995Graduate Student Poster AwardBiology Department UNM
1995Travel AwardSociety for the Advancement of Chicanos and Native Americans in Science Graduate Student
1995Travel AwardAmerican Society of Cell Biology, Minority Graduate Student
1994Travel AwardLa Jolla Cancer Research Center (Burnham Institute) Graduate Student
toggle toggle Professional Community Engagement
YearOrganizationRoleType of Service
2007-2008NSF (Genes and Genomes Division, Integrative Organismal Biology Division)External Grant Reviewer 
2004Mid-West C. elegans Regional MeetingSeminar Moderator 
2004-2006Graduate Student Research DayFaculty Advisor 
2003, 2007McNair Scholar ResearchJudge 
2003-2006Biology Graduate Student AssociationFaculty Advisor 
2002, 2004SACNAS Undergraduate Research Poster PresentationAbstract Reviewer and Judge 
2002-2006UNT Biology Department Undergraduate Club, Alpha DeltaFaculty Advisor 
 U.S. EPA- ORD-NCERExternal Grant Reviewer 
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